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News and Views
Nature Medicine 13, 26 - 28 (2007)
doi:10.1038/nm0107-26
IL-23: a master regulator in Crohn disease
Markus F Neurath1
- Markus F. Neurath is in the Laboratory of Immunology, First Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany. e-mail: neurath@1-med.klinik.uni-mainz.de
Abstract
Three studies should shift thinking about the causes of inflammatory bowel disease. It seems that researchers have been focusing on the wrong cytokine as a driving force.
An innovative genetic study in people and two other recent studies in mice uncover a key factor in the pathogenesis of inflammatory bowel disease (IBD)1, 2, 3. The research puts the spotlight on the pro-inflammatory cytokine interleukin (IL)-23 (refs.
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