Nature Medicine 2.0 - p1

doi:10.1038/nm0107-1

Abstract - Nature Medicine 2.0 | Full Text - Nature Medicine 2.0 | PDF (65 KB) - Nature Medicine 2.0

Biomarkers trump behavior in mental illness diagnosis - p3

Amanda Leigh Haag

doi:10.1038/nm0107-3

Abstract - Biomarkers trump behavior in mental illness diagnosis | Full Text - Biomarkers trump behavior in mental illness diagnosis | PDF (1,553 KB) - Biomarkers trump behavior in mental illness diagnosis

Alternative medicine loses its champion - p4

Meredith Wadman

doi:10.1038/nm0107-4a

Abstract - Alternative medicine loses its champion | Full Text - Alternative medicine loses its champion | PDF (939 KB) - Alternative medicine loses its champion

Europe's sweeping chemical law puts medicines in peril - p4

Brandon Keim

doi:10.1038/nm1537

Abstract - Europe's sweeping chemical law puts medicines in peril | Full Text - Europe's sweeping chemical law puts medicines in peril | PDF (939 KB) - Europe's sweeping chemical law puts medicines in peril

Abstinence activist to head US family planning - p5

Meredith Wadman

doi:10.1038/nm0107-5a

Abstract - Abstinence activist to head US family planning | Full Text - Abstinence activist to head US family planning | PDF (2,022 KB) - Abstinence activist to head US family planning

Australia embraces cloning research - p5

Simon Grose

doi:10.1038/nm0107-5b

Abstract - Australia embraces cloning research | Full Text - Australia embraces cloning research | PDF (2,022 KB) - Australia embraces cloning research

Practical malaria tests promise results in remote regions - p6

Emily Waltz

doi:10.1038/nm0107-6a

Abstract - Practical malaria tests promise results in remote regions | Full Text - Practical malaria tests promise results in remote regions | PDF (749 KB) - Practical malaria tests promise results in remote regions

Companies balk at California's patent rules for stem cell research - p6

Brandon Keim

doi:10.1038/nm0107-6b

Abstract - Companies balk at California's patent rules for stem cell research | Full Text - Companies balk at California's patent rules for stem cell research | PDF (749 KB) - Companies balk at California's patent rules for stem cell research

Menno de Jong - p7

Alisa Opar

doi:10.1038/nm0107-7

Abstract - Menno de Jong | Full Text - Menno de Jong | PDF (254 KB) - Menno de Jong

News in brief - pp8 - 9

doi:10.1038/nm0107-8

Full Text - News in brief | PDF (1,825 KB) - News in brief

Cluster busters - pp10 - 11

Arran Frood

doi:10.1038/nm0107-10

Abstract - Cluster busters | Full Text - Cluster busters | PDF (919 KB) - Cluster busters

In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' - p13

Alan Hatfield, Samantha Owen & Paul Richard Pilot

doi:10.1038/nm0107-13a

Full Text - In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' | PDF (82 KB) - In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate'

In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' - pp13 - 14

Carlo Gambacorti, Lucia Tornaghi, Anna Franceschino, Rocco Piazza, Gianmarco Corneo & Enrico Pogliani

doi:10.1038/nm0107-13b

Full Text - In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' | PDF (173 KB) - In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate'

In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' - p14

Ehab Atallah, Hagop Kantarjian & Jorge Cortes

doi:10.1038/nm0107-14

Full Text - In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' | PDF (134 KB) - In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate'

In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' - p15

Gianantonio Rosti, Giovanni Martinelli & Michele Baccarani

doi:10.1038/nm0107-15a

Full Text - In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' | PDF (82 KB) - In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate'

In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' - pp15 - 16

Thomas Force

doi:10.1038/nm0107-15b

Full Text - In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' | PDF (95 KB) - In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate'

Is leptin an important physiological regulator of CRP? - pp16 - 17

I Sadaf Farooqi & Stephen O'Rahilly

doi:10.1038/nm0107-16

Full Text - Is leptin an important physiological regulator of CRP? | PDF (93 KB) - Is leptin an important physiological regulator of CRP?

Is leptin an important physiological regulator of CRP? - pp17 - 18

Winston L Hutchinson, Anthony P Coll, J Ruth Gallimore, Glenys A Tennent & Mark B Pepys

doi:10.1038/nm0107-17

Full Text - Is leptin an important physiological regulator of CRP? | PDF (120 KB) - Is leptin an important physiological regulator of CRP?

Is leptin an important physiological regulator of CRP? - pp18 - 19

Arieh Gertler, Leonora Niv-Spector & Shay Reicher

doi:10.1038/nm0107-18

Full Text - Is leptin an important physiological regulator of CRP? | PDF (144 KB) - Is leptin an important physiological regulator of CRP? | Supplementary information

Is leptin an important physiological regulator of CRP? - pp19 - 21

Allan Zhao

doi:10.1038/nm0107-19

Full Text - Is leptin an important physiological regulator of CRP? | PDF (132 KB) - Is leptin an important physiological regulator of CRP?

Specter of a serial killer - p23

doi:10.1038/nm0107-23

Full Text - Specter of a serial killer | PDF (319 KB) - Specter of a serial killer

Bone-breaking cancer treatment - pp25 - 26

G David Roodman

doi:10.1038/nm0107-25

Abstract - Bone-breaking cancer treatment | Full Text - Bone-breaking cancer treatment | PDF (324 KB) - Bone-breaking cancer treatment

See also: Article by Park et al.

IL-23: a master regulator in Crohn disease - pp26 - 28

Markus F Neurath

doi:10.1038/nm0107-26

Abstract - IL-23: a master regulator in Crohn disease | Full Text - IL-23: a master regulator in Crohn disease | PDF (159 KB) - IL-23: a master regulator in Crohn disease

Scanning The Genome - p27

Kyle Vogan

doi:10.1038/nm0107-27

Full Text - Scanning The Genome | PDF (77 KB) - Scanning The Genome

A 'good death' for tumor immunology - pp28 - 30

Walter J Storkus & Louis D Falo, Jr

doi:10.1038/nm0107-28

Abstract - A 'good death' for tumor immunology | Full Text - A 'good death' for tumor immunology | PDF (780 KB) - A 'good death' for tumor immunology

See also: Article by Obeid et al.

Hope in sight for retinoblastoma - pp30 - 31

Julien Sage

doi:10.1038/nm0107-30

Abstract - Hope in sight for retinoblastoma | Full Text - Hope in sight for retinoblastoma | PDF (132 KB) - Hope in sight for retinoblastoma

Bad signals jam organelle traffic - pp31 - 32

Esteban C Dell'Angelica

doi:10.1038/nm0107-31

Abstract - Bad signals jam organelle traffic | Full Text - Bad signals jam organelle traffic | PDF (241 KB) - Bad signals jam organelle traffic

See also: Article by Bohn et al.

Singling out heart cells - p33

Michael Basson

doi:10.1038/nm0107-33

Abstract - Singling out heart cells | Full Text - Singling out heart cells | PDF (870 KB) - Singling out heart cells

Research Highlights - p34

doi:10.1038/nm0107-34

Full Text - Research Highlights | PDF (594 KB) - Research Highlights

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors - pp35 - 37

Christel Rousseaux, Xavier Thuru, Agathe Gelot, Nicolas Barnich, Christel Neut, Laurent Dubuquoy, Caroline Dubuquoy, Emilie Merour, Karen Geboes, Mathias Chamaillard, Arthur Ouwehand, Greg Leyer, Didier Carcano, Jean-Frédéric Colombel, Denis Ardid & Pierre Desreumaux

doi:10.1038/nm1521

Abstract - Lactobacillus acidophilus: modulates intestinal pain and induces opioid and cannabinoid receptors | Full Text - Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors | PDF (200 KB) - Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors

A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14 - pp38 - 45

Georg Bohn, Anna Allroth, Gudrun Brandes, Jens Thiel, Erik Glocker, Alejandro A Schäffer, Chozhavendan Rathinam, Nicole Taub, David Teis, Cornelia Zeidler, Ricardo A Dewey, Robert Geffers, Jan Buer, Lukas A Huber, Karl Welte, Bodo Grimbacher & Christoph Klein

doi:10.1038/nm1528

Abstract - A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14 | Full Text - A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14 | PDF (697 KB) - A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14 | Supplementary information

See also: News and Views by Dell'Angelica

CD8⁺ T-cell responses to different HIV proteins have discordant associations with viral load - pp46 - 53

Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I Mullins, David Heckerman, Bruce D Walker & Philip Goulder

doi:10.1038/nm1520

Abstract - CD8: +: T-cell responses to different HIV proteins have discordant associations with viral load | Full Text - CD8+ T-cell responses to different HIV proteins have discordant associations with viral load | PDF (492 KB) - CD8+ T-cell responses to different HIV proteins have discordant associations with viral load | Supplementary information

Calreticulin exposure dictates the immunogenicity of cancer cell death - pp54 - 61

Michel Obeid, Antoine Tesniere, François Ghiringhelli, Gian Maria Fimia, Lionel Apetoh, Jean-Luc Perfettini, Maria Castedo, Grégoire Mignot, Theoharis Panaretakis, Noelia Casares, Didier Métivier, Nathanael Larochette, Peter van Endert, Fabiola Ciccosanti, Mauro Piacentini, Laurence Zitvogel & Guido Kroemer

doi:10.1038/nm1523

Abstract - Calreticulin exposure dictates the immunogenicity of cancer cell death | Full Text - Calreticulin exposure dictates the immunogenicity of cancer cell death | PDF (477 KB) - Calreticulin exposure dictates the immunogenicity of cancer cell death | Supplementary information

See also: News and Views by Storkus & Falo

NF-B in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF - pp62 - 69

Bae Keun Park, Honglai Zhang, Qinghua Zeng, Jinlu Dai, Evan T Keller, Thomas Giordano, Keni Gu, Veena Shah, Lei Pei, Richard J Zarbo, Laurie McCauley, Songtao Shi, Shaoqiong Chen & Cun-Yu Wang

doi:10.1038/nm1519

Abstract - NF-[kappa]B in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF | Full Text - NF-B in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF | PDF (859 KB) - NF-B in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF | Supplementary information

See also: News and Views by Roodman

Targeting the NF-B signaling pathway in Notch1-induced T-cell leukemia - pp70 - 77

Tomas Vilimas, Joaquina Mascarenhas, Teresa Palomero, Malay Mandal, Silvia Buonamici, Fanyong Meng, Benjamín Thompson, Christina Spaulding, Sami Macaroun, Maria-Luisa Alegre, Barbara L Kee, Adolfo Ferrando, Lucio Miele & Iannis Aifantis

doi:10.1038/nm1524

Abstract - Targeting the NF-[kappa]B signaling pathway in Notch1-induced T-cell leukemia | Full Text - Targeting the NF-B signaling pathway in Notch1-induced T-cell leukemia | PDF (545 KB) - Targeting the NF-B signaling pathway in Notch1-induced T-cell leukemia | Supplementary information

Chromosome 5q deletion and epigenetic suppression of the gene encoding -catenin (CTNNA1) in myeloid cell transformation - pp78 - 83

Ting Xi Liu, Michael W Becker, Jaroslav Jelinek, Wen-Shu Wu, Min Deng, Natallia Mikhalkevich, Karl Hsu, Clara D Bloomfield, Richard M Stone, Daniel J DeAngelo, Ilene A Galinsky, Jean-Pierre Issa, Michael F Clarke & A Thomas Look

doi:10.1038/nm1512

First paragraph - Chromosome 5q deletion and epigenetic suppression of the gene encoding [alpha]-catenin (: CTNNA1: ) in myeloid cell transformation | Full Text - Chromosome 5q deletion and epigenetic suppression of the gene encoding -catenin (CTNNA1) in myeloid cell transformation | PDF (491 KB) - Chromosome 5q deletion and epigenetic suppression of the gene encoding -catenin (CTNNA1) in myeloid cell transformation | Supplementary information

Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma - pp84 - 88

Andrew T Parsa, James S Waldron, Amith Panner, Courtney A Crane, Ian F Parney, Jeffrey J Barry, Kristine E Cachola, Joseph C Murray, Tarik Tihan, Michael C Jensen, Paul S Mischel, David Stokoe & Russell O Pieper

doi:10.1038/nm1517

First paragraph - Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma | Full Text - Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma | PDF (294 KB) - Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma | Supplementary information

Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals - pp89 - 94

Qian Gao, Gabor Mezei, Yongzhan Nie, Yan Rao, Cheol Soo Choi, Ingo Bechmann, Csaba Leranth, Dominique Toran-Allerand, Catherine A Priest, James L Roberts, Xiao-Bing Gao, Charles Mobbs, Gerald I Shulman, Sabrina Diano & Tamas L Horvath

doi:10.1038/nm1525

First paragraph - Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals | Full Text - Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals | PDF (542 KB) - Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals

Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging - pp95 - 99

Jae-Hyun Lee, Yong-Min Huh, Young-wook Jun, Jung-wook Seo, Jung-tak Jang, Ho-Taek Song, Sungjun Kim, Eun-Jin Cho, Ho-Geun Yoon, Jin-Suck Suh & Jinwoo Cheon

doi:10.1038/nm1467

Abstract - Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging | Full Text - Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging | PDF (277 KB) - Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging | Supplementary information

Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants - pp100 - 106

Will Fischer, Simon Perkins, James Theiler, Tanmoy Bhattacharya, Karina Yusim, Robert Funkhouser, Carla Kuiken, Barton Haynes, Norman L Letvin, Bruce D Walker, Beatrice H Hahn & Bette T Korber

doi:10.1038/nm1461

Abstract - Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants | Full Text - Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants | PDF (442 KB) - Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants | Supplementary information