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Volume 13 Issue 1, January 2007

Breast cancer often metastasizes to bone, yet the mechanisms underlying bone colonization and destruction are unclear. In this issue, Park et al. report that expression of the transcription factor NF-κ B in breast cancer cells results in secretion of a cytokine–GM-CSF–that stimulates osteoclast development and mediates bone metastasis. The cover image depicts a scanning electron micrograph of breast cancer cells (Steve Gschmeissner, Photo Researchers, Inc.).

Volume 13 Issue 1

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Editorial

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Correspondence

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Book Review

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News & Views

  • A drug used to counteract low white blood cell counts in individuals with breast cancer may also be inducing bone metastases (pages 26–27).

    • G David Roodman
    News & Views

  • Three studies should shift thinking about the causes of inflammatory bowel disease. It seems that researchers have been focusing on the wrong cytokine as a driving force.

    • Markus F Neurath
    News & Views

  • A class of cell-killing chemotherapeutic agents seems to have an additional benefit. The drugs help prompt the immune system to turn against the tumor (pages 54–61).

    • Walter J Storkus
    • Louis D Falo Jr
    News & Views

  • The retinoblastoma gene (RB) was the first tumor suppressor gene cloned. But, until recently, little clinical progress had been made to target human tumors deficient in RB function. A new approach emerges from studying retinoblastoma tumors.

    • Julien Sage
    News & Views

  • Defects in organelle biogenesis and trafficking underlie a newly described genetic disorder. These defects are traced to the gene encoding a scaffolding protein that coordinates signal transduction events on late endosomes (pages 38–45).

    • Esteban C Dell'Angelica
    News & Views

  • Three studies identify multipotent progenitor cells that can give rise to major cell types of the heart. The findings may lead to improved approaches for heart repair.

    • Michael Basson
    News & Views
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