Nature Medicine 12, 541 - 548 (2006)
Published online: 9 April 2006; | doi:10.1038/nm1383
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPKMatthew J Watt, Nicolas Dzamko, Walter G Thomas, Stefan Rose-John, Matthias Ernst, David Carling, Bruce E Kemp, Mark A Febbraio
& Gregory R Steinberg Supplementary Fig. 1 (pdf 148K)
The CNTFR, IL-6R and LIFR are expressed in red and white mouse muscle. Supplementary Fig. 2 (pdf 172K)
CNTF administration affects STAT signaling and metabolic gene expression in white gastrocnemius muscle. Supplementary Fig. 3 (pdf 168K)
High-fat feeding increases food intake body mass, glucose intolerance and insulin resistance. Supplementary Fig. 4 (pdf 128K)
CNTF treatment rescues high-fat diet–induced decreases in PGC-1 protein expression. Supplementary Fig. 5 (pdf 128K)
The insulin-sensitizing effect of CNTF in muscle cells is dependent upon AMPK activation. Supplementary Table 1 (pdf 24K)
Effects of acute CNTF treatment on markers of inflammation. Supplementary Table 2 (pdf 24K)
Plasma metabolites and adipokines without or with 7 days of CNTF treatment. Supplementary Methods (pdf 28K)
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