Nature Medicine
- 12, 1269 - 1277 (2006)
Published online: 22 October 2006; | doi:10.1038/nm1490
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistenceIrmgard Tegeder, Michael Costigan, Robert S Griffin, Andrea Abele, Inna Belfer, Helmut Schmidt, Corina Ehnert, Jemiel Nejim, Claudiu Marian, Joachim Scholz, Tianxia Wu, Andrew Allchorne, Luda Diatchenko, Alexander M Binshtok, David Goldman, Jan Adolph, Swetha Sama, Steven J Atlas, William A Carlezon, Aram Parsegian, Jörn Lötsch, Roger B Fillingim, William Maixner, Gerd Geisslinger, Mitchell B Max & Clifford J Woolf Supplementary Fig. 1 (pdf 390K)
Analgesic effects of DAHP in neuropathic pain models. Supplementary Fig. 2 (pdf 400K)
DAHP is analgesic when delivered intrathecally but has no activity in the forced swim test. Supplementary Fig. 3 (pdf 400K)
Microarray expression profiles of BH4-related enzymes. Supplementary Fig. 4 (pdf 1890K)
Haplotype block organization of GCH1. Supplementary Table 1 (pdf 90K)
Demographic data of the Lumbar Root Pain study. Supplementary Table 2 (pdf 145K)
Locations and allelic frequencies of 15 GCH1 SNPs. Supplementary Table 3 (pdf 135K)
Primer and probe sequences for 5' nuclease genotyping of 15 .GCH1 markers Supplementary Table 4 (pdf 150K)
Associations of experimental pain with the number of copies of the GCH1 pain-protective haplotype. Supplementary Methods (pdf 120K)
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