The theory that oxidative stress limits lifespan and causes age-related disease rests on experiments in invertebrates and correlative evidence from studies in mammals. This theory now gains a strong experimental basis in mammals.
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References
Schriner, S.E. et al. Science, Published online 5 May 2005 (10.1126/science.1106653).
Wang, Y. et al. Proc. Natl. Acad. Sci. USA 98, 4022–4027 (2001).
Zhang, J. et al. Proc. Natl. Acad. Sci. USA 100, 1116–1121 (2003).
Wang, J., Xiong, S., Xie, C., Markesbery, W.R. & Lovell, M.A. J. Neurochem. 93, 953–962 (2005).
Mecocci, P. et al. Ann. Neurol. 34, 609–616 (1993).
Lin, M.T., Simon, D.K., Ahn, C.H., Kim, L.M. & Beal, M.F. Hum. Mol. Genet. 11, 133–145 (2002).
Trifunovic, A. et al. Nature 429, 417–423 (2004).
Lu, T. et al. Nature 429, 883–891 (2004).
Ruan, H. et al. Proc. Natl. Acad. Sci. USA 99, 2748–2753 (2002).
Moskovitz, J. et al. Proc. Natl. Acad. Sci. USA 98, 12920–12925 (2001).
Mitsui, A. et al. Antioxid. Redox Signal. 4, 693–696 (2002).
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Beal, M. Less stress, longer life. Nat Med 11, 598–599 (2005). https://doi.org/10.1038/nm0605-598
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DOI: https://doi.org/10.1038/nm0605-598
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