Access
To read this story in full you will need to login or make a payment (see right).
Article
Nature Medicine 11, 615 - 622 (2005)
Published online: 8 May 2005 | doi:10.1038/nm1244
Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies
Alexandra Trkola1, Herbert Kuster1, Peter Rusert1, Beda Joos1, Marek Fischer1, Christine Leemann1, Amapola Manrique1, Michael Huber1, Manuela Rehr2, Annette Oxenius2, Rainer Weber1, Gabriela Stiegler3, Brigitta Vcelar3, Hermann Katinger3, Leonardo Aceto1 & Huldrych F Günthard1
Abstract
To determine the protective potential of the humoral immune response against HIV-1 in vivo we evaluated the potency of three neutralizing antibodies (2G12, 2F5 and 4E10) in suppressing viral rebound in six acutely and eight chronically HIV-1–infected individuals undergoing interruption of antiretroviral treatment (ART). Only two of eight chronically infected individuals showed evidence of a delay in viral rebound during the passive immunization. Rebound in antibody-treated acutely infected individuals upon cessation of ART was substantially later than in a control group of 12 individuals with acute infection. Escape mutant analysis showed that the activity of 2G12 was crucial for the in vivo effect of the neutralizing antibody cocktail. By providing further direct evidence of the potency, breadth and titers of neutralizing antibodies that are required for in vivo activity, these data underline both the potential and the limits of humoral immunity in controlling HIV-1 infection.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Neutralizing antibodies take a swipe at HIV in vivoNature Medicine News and Views (01 Jun 2005)
Dangerous T-cell amnesiaNature Medicine News and Views (01 May 1999)
See all 9 matches for News And ViewsRESEARCH
Hyperglycemia Enhances DNA Fragmentation After Transient Cerebral IschemiaJournal of Cerebral Blood Flow & Metabolism Original Article
Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodiesNature Medicine Article (01 Feb 2000)
See all 46 matches for Research