Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature Medicine 11, 599 - 600 (2005)
doi:10.1038/nm0605-599
A low-carb diet for a high-octane pathogen
- The authors are in the Tuberculosis Research Section, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, Maryland 20852, USA. e-mail: cbarry@niaid.nih.gov
Abstract
Mycobacterium tuberculosis adapts to the low-glucose conditions in its host by using lipids as a fuel source. This adaptation reveals a weak flank that might be exploited in drug development, as shown in work on mice and human cells (pages 638–644).
More than a century has elapsed since the seminal discovery by Robert Koch that Mycobacterium tuberculosis is the etiological agent of tuberculosis. Koch's discovery hinged on figuring out how to coax the finicky, slow-growing bacterium to thrive on laboratory Petri plates with just the right mixture of nutrients.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Mycobacterium tuberculosis virulence: lipids inside and outNature Medicine News and Views (01 Mar 2007)
Mycobacterium tuberculosis virulence: lipids inside and outNature Medicine News and Views (01 Mar 2007)
See all 4 matches for News And ViewsRESEARCH
Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulenceNature Medicine Article (01 Jun 2005)
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyaseNature Letters to Editor (17 Aug 2000)
See all 3 matches for Research