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Nature Medicine 11, 123 - 124 (2005)
doi:10.1038/nm0205-123
Staying in SHIP shape
Stuart J Decker1 & Alan R Saltiel1
- The authors are at the Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA. e-mail: saltiel@umich.edu
Abstract
The phosphatase SHIP2 has been the focus of drug development efforts for diabetes. This distinction is based in part on work suggesting that the molecule is central to the regulation of glucose levels in tissues and blood. An analysis of a SHIP2 knockout mouse changes this viewpoint and provides new directions for therapeutic intervention (pages 199–205).
The dramatic increase in type 2 diabetes and obesity is a major epidemic in the developed world and many parts of the undeveloped world. At the heart of this problem lies insulin resistance, the earliest detectable lesion in the development of diabetes.
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