Nature Medicine 11, 1293 - 1294 (2005)
Published online: 6 November 2005; | doi:10.1038/nm1321
Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitorRonald S Veazey1, 4, Martin S Springer2, 4, Preston A Marx1, Jason Dufour1, Per Johan Klasse3
& John P Moore31
Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, Louisiana 70433, USA. 2
Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, New Jersey 07065, USA. 3
Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, W-805, New York, New York 10021, USA. 4
These authors contributed equally to this work.
Correspondence should be addressed to John P Moore jpm2003@med.cornell.edu Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10–14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.
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