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Cannabinoids cool the intestine

Cannabinoids inhibit motility and secretion in the intestine. They are now assigned the additional task of curbing excessive inflammation, suggesting that drugs targeting the endogenous cannabinoid system could be exploited for inflammatory bowel disease.

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Figure 1: Cellular source and proposed targets of anti-inflammatory endocannabinoids in IBD.

Deborah Maizels

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Kunos, G., Pacher, P. Cannabinoids cool the intestine. Nat Med 10, 678–679 (2004). https://doi.org/10.1038/nm0704-678

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