Journal home
Advance online publication
Current issue
Archive
Press releases
Supplements
Focuses
Guide to authors
Online submissionOnline submission
For referees
Free online issue
Contact the journal
Subscribe
Advertising
work@npg
Reprints and permissions
About this site
For librarians
 
NPG Resources
Nature
Nature Reviews
Nature Immunology
Nature Cell Biology
Nature Genetics
news@nature.com
Nature Conferences
Dissect Medicine
NPG Subject areas
Biotechnology
Cancer
Chemistry
Clinical Medicine
Dentistry
Development
Drug Discovery
Earth Sciences
Evolution & Ecology
Genetics
Immunology
Materials Science
Medical Research
Microbiology
Molecular Cell Biology
Neuroscience
Pharmacology
Physics
Browse all publications
News and Views
Celebrating our tenth year
Contents Editorial News   Classics  
Historical News & Views Historical Perspectives Historical Research Highlights


Nature Medicine  10, 1304 - 1305 (2004)
doi:10.1038/nm1204-1304

Antibody diversity: one enzyme to rule them all

Michel C Nussenzweig1 & Frederick W Alt2

1  Michael C. Nussenzweig is in the Laboratory of Molecular Immunology and the Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA. nussen@mail.rockefeller.edu

2  Frederick W. Alt is at the Howard Hughes Medical Institute, The Children's Hospital, and The Center for Blood Research and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. alt@enders.tch.harvard.edu

Three reactions diversify antibody genes in human somatic cells of the B lineage: VDJ recombination, somatic hypermutation and class-switch recombination. The discovery of activation-induced cytidine deaminase (AID) has led to the elucidation of a unified molecular mechanism for initiation of the last two reactions and suggests why B cells undergoing these reactions are prone to cancer-associated DNA damage.

MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.

NEWS AND VIEWS

Class switching and Myc translocation: how does DNA break?

Nature Immunology News and Views (01 Nov 2004)

Mutations in AID and UNG extend the function of AID

Nature Immunology News and Views (01 Oct 2003)

See all 8 matches for News And Views
 Top
Abstract
Previous | Next
Table of contents
Full textFull text
Download PDFDownload PDF
Send to a friendSend to a friend

Open Innovation Challenges

naturejobs

Figures & Tables
Export citation
natureproducts

Search buyers guide:

 
ADVERTISEMENT
 
Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
Journal home | Advance online publication | Current issue | Archive | Press releases | Supplements | Focuses | For authors | Online submission | For referees | Free online issue | About the journal | Contact the journal | Subscribe | Advertising | work@npg | Reprints and permissions | About this site | For librarians
Nature Publishing Group, publisher of Nature, and other science journals and reference works©2004 Nature Publishing Group | Privacy policy