Two studies in the mid-1990s cracked a mystery of innate immunity–how foreign invaders are recognized. One study found that signaling through Toll-like receptor 4 activated the immune response. Another identified the signal: lipopolysaccharide (LPS), a cell envelope component of Gram-negative bacteria. The discoveries brought full circle observations that began with starfish in the 1880s.
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References
Metschnikoff, E. Archiv f. pathologische Anatomie und Physiologie und f. klinische Medicin 96, 177–195 (1884).
Janeway, C.A., Jr. Cold Spring Harb. Symp. Quant. Biol. 54, 1–13 (1989).
Medzhitov, R., Preston-Hurlburt, P. & Janeway, C.A.J. Nature 388, 394–397 (1997).
Poltorak, A. et al. Science 282, 2085–2088 (1998).
Yang, R.B. et al. Nature 395, 284–288 (1998).
Brightbill, H.D. et al. Science 285, 732–736 (1999).
Aliprantis, A.O. et al. Science 285, 736–739 (1999).
Hemmi, H. et al. Nature 408, 740–745 (2000).
Hayashi, F. et al. Nature 410, 1099–1103 (2001).
Alexopoulou, L., Holt, A.C., Medzhitov, R. & Flavell, R.A. Nature 413, 732–738 (2001).
Diebold, S.S., Kaisho, T., Hemmi, H., Akira, S. & Reis e Sousa . Science 303, 1529–1531 (2004).
Blander, J.M. & Medzhitov, R. Science 304, 1014–1018 (2004).
Doyle, S.E. et al. J. Exp. Med. 199, 81–90 (2004).
Thoma-Uszynski, S. et al. Science 291, 1544–1547 (2001).
Hertz, C.J. et al. J. Immunol. 171, 6820–6826 (2003).
Doyle, S. et al. Immunity 17, 251–263 (2002).
Kawai, T. et al. J. Immunol. 167, 5887–5894 (2001).
Kawai, T. et al. Nat. Immunol. 5, 1061–1068 (2004).
Inohara, N. et al. J. Biol. Chem. 278, 5509–5512 (2003).
Girardin, S.E. et al. Science 300, 1584–1587 (2003).
Krutzik, S.R. et al. Nat. Med. 9, 525–532 (2003).
Alexopoulou, L. et al. Nat. Med. 8, 878–884 (2002).
Oliveira, R.B. et al. Infect. Immun. 71, 1427–1433 (2003).
Leadbetter, E.A. et al. Nature 416, 603–607 (2002).
Hemmi, H. et al. Nat. Immunol. 3, 196–200 (2002).
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Modlin, R., Cheng, G. From plankton to pathogen recognition. Nat Med 10, 1173–1174 (2004). https://doi.org/10.1038/nm1104-1173
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DOI: https://doi.org/10.1038/nm1104-1173
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