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Journal home Advance online publication Current issue Archive Press releases Supplements Focuses Guide to authors Online submission For referees Free online issue Contact the journal Subscribe Advertising work@npg Reprints and permissions About this site For librarians   NPG Resources Nature Nature Reviews Nature Immunology Nature Cell Biology Nature Genetics news@nature.com Nature Conferences Dissect Medicine NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications News and Views Contents Editorial News   Classics   Historical News & Views Historical Perspectives Historical Research Highlights Nature Medicine  10, 1052 - 1053 (2004) doi:10.1038/nm1004-1052 Easing the brakes on spinal cord repair Lisa McKerracher1 & Samuel David2 1  Lisa McKerracher is in Department of Pathology and Cell Biology, Université de Montréal, Montreal, Quebec H3T 1J4, Canada, and at BioAxone Therapeutic, Inc., Montreal, Canada. lisa.mckerracher@bioaxone.com 2  Samuel David is at the Centre for Research in Neuroscience, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada. The inability of axons to regenerate in the injured spinal cord leads to permanent paralysis. The discovery and cloning of Nogo, one of the axon growth inhibitors in myelin, was a major step in understanding the failure of axon regeneration. Subsequent work identifying the Nogo receptor and associated signaling factors has renewed optimism for the development of treatments to ease the brakes on axon regeneration after spinal cord trauma. MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated. NEWS AND VIEWS Neurobiology Nogo in nerve regeneration Nature News and Views (27 Jan 2000) Making the connections in nerve regeneration Nature Medicine News and Views (01 Jan 1996) RESEARCH PKC mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regeneration Nature Neuroscience Article (01 Mar 2004) The role of complement in immunological demyelination of the mammalian spinal cord Spinal Cord Original Article See all 12 matches for Research  Top Abstract Previous | Next Table of contents Full text Download PDF Send to a friend Open Innovation Challenges Delayed Burst Release Deadline: Mar 04 2010 Reward: $20,000 USD A mechanism is desired that will have little or no release until triggered and then substantially re... Novel Approaches to Protecting Maize from Insect Damage Deadline: Jan 31 2010 Reward: $20,000 USD The Seeker is looking for novel approaches to protecting maize from insect damage. This Challenge re... More Challenges Powered by: nature jobs Full-Professor of Heart and Thoracic Surgery (W3) (f / m) Friedrich-Schiller-University Jena Jena Germany Medical Writer Cactus Global Mumbai 400053 India More science jobs Post a job for free Figures & Tables Export citation Search buyers guide:   ADVERTISEMENT

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