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Antisense development has required diligent efforts by many labs to allow it to progress. Improved methods have helped to transgress many barriers, resulting in a vibrant technology geared towards generating new human therapuetics.
The discovery of effective disease treatments has slowed. This may be related to a misunderstanding of the treatment-discovery process, and an underappreciation of clinical investigations and off-label drug studies.
The level of scientific understanding required to develop a successful AIDS vaccine is still lacking, although the elements needed to pursue a practical and productive vaccine development program can be defined.
We now have a number of effective drugs for osteoporosis. However, close inspection of clinical trials results suggests we should aim for even better ones.
Internalization of targeted therapeutics is often needed for efficacy, but also alters drug penetration of a tissue. A new model explores the trade-offs of intracellular drug trafficking.
