Abstract
We conducted genome-wide association studies of non-Hodgkin lymphoma using Illumina HumanHap550 BeadChips to identify subtype-specific associations in follicular, diffuse large B-cell and chronic lymphocytic leukemia/small lymphocytic lymphomas. We found that rs6457327 on 6p21.33 was associated with susceptibility to follicular lymphoma (FL; N = 189 cases, 592 controls) with validation in another 456 FL cases and 2,785 controls (combined allelic P = 4.7 × 10−11). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1).
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Acknowledgements
We thank S. Leach, J. Schuetz and A. MacArthur for assistance. This work was supported by US National Institutes of Health grants CA122663 (C.F.S.), CA104862 (M.T.S.), and CA45614, CA89745 and CA87014 (E.A.H.); the American Cancer Society (IRG-07-06401), the US National Institutes of Health (HL086528) and a charitable donation by Sylvia Chase (K.M.B.); the Stardust Foundation (D.W.C.); the Canadian Cancer Society and National Cancer Institute of Canada, and the Canadian Institutes of Health Research (J.J.S. and A.B.-W.); and the German José Carreras Leukemia Foundation (DJCLS R04/08 and R07/26f; A.N.).
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C.F.S., J.J.S., A.B.-W., E.A.H. and N.B. are principal investigators for the participating studies; L.A. and J.R. did DNA extraction, normalization and quality control; K.M.B. and K.I. prepared DNA pools and performed the genome scan and analysis; D.W.C., C.F.S., K.M.B., M.T.S. and L.Z. consulted on study design; L.A. undertook genotyping; J.D.C. performed expression analysis; D.W.C., P.M.B., A.N. and L.C. performed the statistical analyses; L.C. and E.H. conducted bioinformatics analyses; C.S.F., L.C. and K.M.B. wrote the manuscript.
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Skibola, C., Bracci, P., Halperin, E. et al. Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma. Nat Genet 41, 873–875 (2009). https://doi.org/10.1038/ng.419
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DOI: https://doi.org/10.1038/ng.419
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