1. Svati H. Shah and Geoffrey S. Pitt are in the Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina, USA. e-mail: svati.shah@duke.edu

Abstract

Prolongation of the electrocardiographic QT interval, a measure of cardiac repolarization, is associated with arrhythmogenic disorders and is a risk factor for sudden cardiac death. Two genome-wide association studies (GWAS) of variation in the QT interval in population-based cohorts now report association with variants in a subset of ion channel genes and other new associations.

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