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Letter

Nature Genetics 41, 365–370 (1 March 2009) | doi:10.1038/ng.317

A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function

Sonia A Melo , Santiago Ropero , Catia Moutinho , Lauri A Aaltonen , Hiroyuki Yamamoto , George A Calin , Simona Rossi , Agustin F Fernandez , Fatima Carneiro , Carla Oliveira , Bibiana Ferreira , Chang-Gong Liu , Alberto Villanueva , Gabriel Capella , Simo Schwartz Jr , Ramin Shiekhattar & Manel Esteller

microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by targeting messenger RNA (mRNA) transcripts. Recently, a miRNA expression profile of human tumors has been characterized by an overall miRNA downregulation.