Letter abstract
Nature Genetics 41, 205 - 210 (2009)
Published online: 25 January 2009 | doi:10.1038/ng.310
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21
Xue-Jun Zhang1,2,3, Wei Huang4,5, Sen Yang1,2,3, Liang-Dan Sun1,2,3, Feng-Yu Zhang1,2,3, Qi-Xing Zhu1,2,3, Fu-Ren Zhang3,6, Chi Zhang1,2,3, Wen-Hui Du1,2,3, Xiong-Ming Pu3,7, Hui Li1,2,3, Feng-Li Xiao1,2,3, Zai-Xing Wang1,2,3, Yong Cui1,2,3, Fei Hao8, Jie Zheng9, Xue-Qin Yang3,10, Hui Cheng1,2,3, Chun-Di He11, Xiao-Ming Liu12, Li-Min Xu13, Hou-Feng Zheng1,2,3, Shu-Mei Zhang1,2,3, Jian-Zhong Zhang14, Hong-Yan Wang1,2,3, Yi-Lin Cheng1,2,3, Bi-Hua Ji15, Qiao-Yun Fang2, Yu-Zhen Li16, Fu-Sheng Zhou2, Jian-Wen Han1,2,3, Cheng Quan1,2,3, Bin Chen1,2,3, Jun-Lin Liu1,2,3, Da Lin1,2,3, Li Fan1,2,3, An-Ping Zhang1,2,3, Sheng-Xiu Liu1,2,3, Chun-Jun Yang1,2,3, Pei-Guang Wang1,2,3, Wen-Ming Zhou1,2,3, Guo-Shu Lin1,2,3, Wei-Dong Wu3,7, Xing Fan1,2,3, Min Gao1,2,3, Bao-Qi Yang3,6, Wen-Sheng Lu1,2,3, Zheng Zhang1,2,3, Kun-Ju Zhu1,2,3, Song-Ke Shen1,2,3, Min Li1,2,3, Xiao-Yan Zhang1,2,3, Ting-Ting Cao1,2,3, Wei Ren1,2,3, Xin Zhang1,2,3, Jun He1,2,3, Xian-Fa Tang1,2,3, Shun Lu1,2,3, Jian-Qiang Yang1,2,3, Lin Zhang1,2,3, Dan-Ni Wang1,2,3, Feng Yuan1,2,3, Xian-Yong Yin1,2,3, Hong-Jie Huang4,5, Hai-Feng Wang4,5, Xin-Yi Lin17 & Jian-Jun Liu1,2,17
We report the first large genome-wide association study (GWAS) in a Chinese population to identify susceptibility variants for psoriasis using a two-stage case-control design. In the first stage, we carried out a genome-wide association analysis in 1,139 cases and 1,132 controls of Chinese Han ancestry using Illumina Human 610-Quad BeadChips. In the second stage, we took top SNPs forward for replication in two independent samples of 5,182 cases and 6,516 controls of Chinese Han ancestry, and 539 cases and 824 controls of Chinese Uygur ancestry. In addition to the strong replication for two known susceptibility loci MHC (rs1265181, P = 1.93 
10-208, OR = 22.62) and IL12B (rs3213094, Pcombined= 2.58 10-26, OR = 0.78), we identified a new susceptibility locus within the LCE gene cluster on 1q21 (rs4085613, Pcombined = 6.69 10-30, OR = 0.76).
- Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China.
- The Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education and Anhui Province, Hefei, Anhui 230032, China.
- Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui 230032, China.
- Chinese National Human Genome Center at Shanghai, Shanghai 201203, China.
- The National Engineering Center for Biochip Design and Engineer in Shanghai, Shanghai 201203, China.
- Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong 250022, China.
- Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumchi, Xinjiang 830001, China.
- Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
- Department of Dermatology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China.
- Department of Dermatology, The General Hospital of Air Force, PLA, Beijing 100036, China.
- Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, Liaoning 110001, China.
- Department of Dermatology, the 1st Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China.
- Department of Dermatology, Changzheng Hospital, Tianjin 300120, China.
- Department of Dermatology, Peking University People's Hospital, Beijing 100044, China.
- Department of Dermatology, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, China.
- Department of Dermatology, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China.
- Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.
Correspondence to: Xue-Jun Zhang1,2,3 e-mail: ayzxj@vip.sina.com
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