Access

Letter

Nature Genetics 41, 1122–1126 (1 October 2009) | doi:10.1038/ng.448

Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility

Julius Gudmundsson , Patrick Sulem , Daniel F Gudbjartsson , Thorarinn Blondal , Arnaldur Gylfason , Bjarni A Agnarsson , Kristrun R Benediktsdottir , Droplaug N Magnusdottir , Gudbjorg Orlygsdottir , Margret Jakobsdottir , Simon N Stacey , Asgeir Sigurdsson , Tiina Wahlfors , Teuvo Tammela , Joan P Breyer , Kate M McReynolds , Kevin M Bradley , Berta Saez , Javier Godino , Sebastian Navarrete , Fernando Fuertes , Laura Murillo , Eduardo Polo , Katja K Aben , Inge M van Oort , Brian K Suarez , Brian T Helfand , Donghui Kan , Carlo Zanon , Michael L Frigge , Kristleifur Kristjansson , Jeffrey R Gulcher , Gudmundur V Einarsson , Eirikur Jonsson , William J Catalona , Jose I Mayordomo , Lambertus A Kiemeney , Jeffrey R Smith , Johanna Schleutker , Rosa B Barkardottir , Augustine Kong , Unnur Thorsteinsdottir , Thorunn Rafnar & Kari Stefansson

We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 |[times]| 10|[minus]|10) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 |[times]| 10|[minus]|15) and rs445114[T] (OR = 1.14, P = 4.7 |[times]| 10|[minus]|10), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 |[times]| 10|[minus]|11) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 |[times]| 10|[minus]|12). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population.