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Nature Genetics 41, 1094–1099 (1 October 2009) | doi:10.1038/ng.439

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

Jean-Charles Lambert , Simon Heath , Gael Even , Dominique Campion , Kristel Sleegers , Mikko Hiltunen , Onofre Combarros , Diana Zelenika , Maria J Bullido , B|[eacute]|atrice Tavernier , Luc Letenneur , Karolien Bettens , Claudine Berr , Florence Pasquier , Nathalie Fi|[eacute]|vet , Pascale Barberger-Gateau , Sebastiaan Engelborghs , Peter De Deyn , Ignacio Mateo , Ana Franck , Seppo Helisalmi , Elisa Porcellini , Olivier Hanon , Marian M de Pancorbo , Corinne Lendon , Carole Dufouil , C|[eacute]|line Jaillard , Thierry Leveillard , Victoria Alvarez , Paolo Bosco , Michelangelo Mancuso , Francesco Panza , Benedetta Nacmias , Paola Boss|[ugrave]| , Paola Piccardi , Giorgio Annoni , Davide Seripa , Daniela Galimberti , Didier Hannequin , Federico Licastro , Hilkka Soininen , Karen Ritchie , H|[eacute]|l|[egrave]|ne Blanch|[eacute]| , Jean-Fran|[ccedil]|ois Dartigues , Christophe Tzourio , Ivo Gut , Christine Van Broeckhoven , Annick Alp|[eacute]|rovitch , Mark Lathrop & Philippe Amouyel

The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we conducted a large genome-wide association study of 2,032 individuals from France with Alzheimer's disease (cases) and 5,328 controls.