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Brief Communication

Nature Genetics 40, 838–840 (1 July 2008) | doi:10.1038/ng.163

Common sequence variants on 20q11.22 confer melanoma susceptibility

Kevin M Brown , Stuart MacGregor , Grant W Montgomery , David W Craig , Zhen Zhen Zhao , Kelly Iyadurai , Anjali K Henders , Nils Homer , Megan J Campbell , Mitchell Stark , Shane Thomas , Helen Schmid , Elizabeth A Holland , Elizabeth M Gillanders , David L Duffy , Judith A Maskiell , Jodie Jetann , Megan Ferguson , Dietrich A Stephan , Anne E Cust , David Whiteman , Adele Green , H|[aring]|kan Olsson , Susana Puig , Paola Ghiorzo , Johan Hansson , Florence Demenais , Alisa M Goldstein , Nelleke A Gruis , David E Elder , Julia Newton Bishop , Richard F Kefford , Graham G Giles , Bruce K Armstrong , Joanne F Aitken , John L Hopper , Nicholas G Martin , Jeffrey M Trent , Graham J Mann & Nicholas K Hayward

We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P |[minus]|15).