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Letter

Nature Genetics 40, 897–903 (1 July 2008) | doi:10.1038/ng.154

Combinatorial patterns of histone acetylations and methylations in the human genome

Zhibin Wang , Chongzhi Zang , Jeffrey A Rosenfeld , Dustin E Schones , Artem Barski , Suresh Cuddapah , Kairong Cui , Tae-Young Roh , Weiqun Peng , Michael Q Zhang & Keji Zhao

Histones are characterized by numerous posttranslational modifications that influence gene transcription. However, because of the lack of global distribution data in higher eukaryotic systems, the extent to which gene-specific combinatorial patterns of histone modifications exist remains to be determined.