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Brief Communication

Nature Genetics 40, 713–715 (1 June 2008) | doi:10.1038/ng.148

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

Andre Franke , Tobias Balschun , Tom H Karlsen , J|[uuml]|rgen Hedderich , Sandra May , Tim Lu , D|[ouml]|rthe Schuldt , Susanna Nikolaus , Philip Rosenstiel , Michael Krawczak & Stefan Schreiber

Following up on recent genome-wide association studies (GWAS) of Crohn's disease, we investigated 50 previously reported susceptibility loci in a German sample of individuals with Crohn's disease (n = 1,850) or ulcerative colitis (n = 1,103) and healthy controls (n = 1,817). Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection.