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Volume 40 Issue 6, June 2008

Cover Art: Division by Thomas Stavovy from eo art lab www.eoartlab.com

Editorial

  • The XX International Congress of Genetics is July 12–17 in Berlin, Germany.

    Editorial

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Book Review

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News & Views

  • Gene fusions arising from translocations make an important contribution to the development of cancer. A new study uses high-throughput sequencing to characterize such fusions at an unprecedented level of resolution.

    • Sverre Heim
    • Felix Mitelman
    News & Views
  • Genome-wide association studies in Crohn's disease have convincingly identified multiple risk variants. Two new studies in ulcerative colitis, a related inflammatory bowel disease, now reveal a glimpse of the overlapping spectrum of risk variants, highlighting both the commonalities and the unique features of these disorders.

    • Patrick C Dubois
    • David A van Heel
    News & Views
  • A new paper reports an individual with the major features of Prader-Willi syndrome (PWS) and a microdeletion in 15q11–q13 removing a cluster of small nucleolar RNAs (snoRNAs). This report provides virtually conclusive evidence that PWS is caused by loss of expression of the C/D box HBII-85 snoRNAs.

    • Jo Peters
    News & Views
  • The X chromosome has been thought to be mostly silent after meiosis in males. A new study reports that this is not the case for a set of multicopy genes often arranged in giant palindromes and highly expressed in spermatids.

    • Christine M Disteche
    News & Views
  • Digital clubbing has been recognized since the time of the ancient Greeks as a sign of systemic disease. Now, a new study identifies a role for prostaglandin E2 in the pathogenesis of digital clubbing observed in familial hypertrophic osteoarthropathy.

    • Kenneth G Coggins
    • Thomas M Coffman
    • Beverly H Koller
    News & Views
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Perspective

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Brief Communication

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Article

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Letter

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