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Letter

Nature Genetics 40, 340–345 (1 March 2008) | doi:10.1038/ng.78

Natural selection has driven population differentiation in modern humans

Luis B Barreiro , Guillaume Laval , H|[eacute]|l|[egrave]|ne Quach , Etienne Patin & Llu|[iacute]|s Quintana-Murci

The considerable range of observed phenotypic variation in human populations may reflect, in part, distinctive processes of natural selection and adaptation to variable environmental conditions. Although recent genome-wide studies have identified candidate regions under selection, it is not yet clear how natural selection has shaped population differentiation.