Brief Communication abstract
Nature Genetics 40, 281 - 283 (2008)
Published online: 10 February 2008 | doi:10.1038/ng.89
Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer
Julius Gudmundsson1,26, Patrick Sulem1,26, Thorunn Rafnar1, Jon T Bergthorsson1, Andrei Manolescu1, Daniel Gudbjartsson1, Bjarni A Agnarsson2, Asgeir Sigurdsson1, Kristrun R Benediktsdottir2, Thorarinn Blondal1, Margret Jakobsdottir1, Simon N Stacey1, Jelena Kostic1, Kari T Kristinsson1, Birgitta Birgisdottir1, Shyamali Ghosh1, Droplaug N Magnusdottir1, Steinunn Thorlacius1, Gudmar Thorleifsson1, S Lilly Zheng3, Jielin Sun3, Bao-Li Chang3, J Bradford Elmore4, Joan P Breyer4, Kate M McReynolds4, Kevin M Bradley4, Brian L Yaspan4, Fredrik Wiklund5, Par Stattin6, Sara Lindström5, Hans-Olov Adami5,7, Shannon K McDonnell8, Daniel J Schaid8, Julie M Cunningham9, Liang Wang9, James R Cerhan8, Jennifer L St Sauver8, Sara D Isaacs10, Kathleen E Wiley10, Alan W Partin10, Patrick C Walsh10, Sonia Polo11, Manuel Ruiz-Echarri12, Sebastian Navarrete13, Fernando Fuertes13, Berta Saez14,15, Javier Godino14, Philip C Weijerman16, Dorine W Swinkels17, Katja K Aben18,19, J Alfred Witjes20, Brian K Suarez21, Brian T Helfand22, Michael L Frigge1, Kristleifur Kristjansson1, Carole Ober23, Eirikur Jonsson24, Gudmundur V Einarsson24, Jianfeng Xu3, Henrik Gronberg5, Jeffrey R Smith4,25, Stephen N Thibodeau9, William B Isaacs10, William J Catalona22, Jose I Mayordomo12,14,15, Lambertus A Kiemeney18,19,20, Rosa B Barkardottir2, Jeffrey R Gulcher1, Unnur Thorsteinsdottir1, Augustine Kong1 & Kari Stefansson1
We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 
10-13 and 7.7 10-9, respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.
- deCODE genetics, 101 Reykjavik, Iceland.
- Department of Pathology, Landspitali-University Hospital, 101 Reykjavik, Iceland.
- Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
- Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, S-17177 Stockholm, Sweden.
- Department of Urology, Umea University Hospital, S-90185 Umea, Sweden.
- Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
- Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
- Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
- Brady Urological Institute, Johns Hopkins Medical Institution, Baltimore, Maryland 21209, USA.
- Division of Radiation Oncology, Quiron Hospital, 50009 Zaragoza, Spain.
- Division of Medical Oncology, Lozano Blesa University Hospital, University of Zaragoza, 50009 Zaragoza, Spain.
- Division of Radiation Oncology, Lozano Blesa University Hospital, University of Zaragoza, 50009 Zaragoza, Spain.
- Health Sciences Institute, 50009 Zaragoza, Spain.
- Nanotechnology Institute of Aragon, 50009 Zaragoza, Spain.
- Department of Urology, Rijnstate Hospital, NL-6800 TA Arnhem, The Netherlands.
- Department of Clinical Chemistry, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands.
- Comprehensive Cancer Center East, 6501 BG Nijmegen, The Netherlands.
- Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands.
- Department of Urology, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands.
- Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA.
- Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
- Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA.
- Department of Urology, Landspitali-University Hospital, 101 Reykjavik, Iceland.
- Medical Research Service, VA Tennessee Valley Healthcare System, Nashville, Tennessee 37212, USA.
- These authors contributed equally to this work.
Correspondence to: Kari Stefansson1 e-mail: kstefans@decode.is
Correspondence to: Julius Gudmundsson1,26 e-mail: julius@decode.is
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