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Nature Genetics 40, 132 - 134 (2008)
doi:10.1038/ng0208-132

Hypoxic reprogramming

Daniel P Kelly1

  1. Daniel P. Kelly is in the Center for Cardiovascular Research, Departments of Medicine, Developmental Biology, and Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, USA. e-mail: dkelly@wustl.edu


Many organisms have an amazing capacity to adapt to conditions of low oxygen, but the cellular mechanisms of this are poorly understood. A new study in mice has unveiled a molecular trigger that initiates a cascade of events to reprogram cellular oxygen requirements.

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