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Letter
Nature Genetics 40, 1348–1353 (1 November 2008) | doi:10.1038/ng.230
Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein
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Abstract
In humans, SHH haploinsufficiency results in holoprosencephaly (HPE), a defect in anterior midline formation. Despite the importance of maintaining SHH transcript levels above a critical threshold, we know little about the upstream regulators of SHH expression in the forebrain.
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