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Brief Communication

Nature Genetics 40, 1279–1281 (1 November 2008) | doi:10.1038/ng.228

Susceptibility variants for male-pattern baldness on chromosome 20p11

Axel M Hillmer , Felix F Brockschmidt , Sandra Hanneken , Sibylle Eigelshoven , Michael Steffens , Antonia Flaquer , Stefan Herms , Tim Becker , Anne-Katrin Kort|[uuml]|m , Dale R Nyholt , Zhen Zhen Zhao , Grant W Montgomery , Nicholas G Martin , Thomas W M|[uuml]|hleisen , Margrieta A Alblas , Susanne Moebus , Karl-Heinz J|[ouml]|ckel , Martina Br|[ouml]|cker-Preuss , Raimund Erbel , Roman Reinartz , Regina C Betz , Sven Cichon , Peter Propping , Max P Baur , Thomas F Wienker , Roland Kruse & Markus M N|[ouml]|then

We carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls. We then investigated the 30 best SNPs in an independent replication sample and found highly significant association for five SNPs on chromosome 20p11 (rs2180439 combined P = 2.7 |[times]| 10|[minus]|15).