News and Views
Nature Genetics 40, 1272 - 1273 (2008)
doi:10.1038/ng1108-1272
Wilms tumor and constitutional epigenetic defects
Andrea Riccio1
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Andrea Riccio is at the Department of Environmental Science, Second University of Naples, Caserta 81100, Italy and at the Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Naples 80131, Italy.
e-mail: andrea.riccio@unina2.it
Abstract
Constitutional epigenetic defects affecting the 11p15.5 imprinted region cause a number of syndromic conditions involving birth defects. Now, an analysis of a large cohort of individuals with nonsyndromic Wilms tumor demonstrates the presence of known and newly identified constitutional IGF2-H19 imprinting defects, extending the phenotype associated with soma-wide 11p15.5 imprinting disorders.
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