Article abstract
Nature Genetics 40, 69 - 77 (2008)
Published online: 9 December 2007 | doi:10.1038/ng.2007.54
Ciliary proteins link basal body polarization to planar cell polarity regulation
Chonnettia Jones1, Venus C Roper2, Isabelle Foucher3, Dong Qian1, Boglarka Banizs2, Christine Petit3, Bradley K Yoder2 & Ping Chen1
Abstract
Planar cell polarity (PCP) refers to coordinated polarization of cells within the plane of a cell sheet. A conserved signaling pathway is required for the establishment of PCP in epithelial tissues and for polarized cellular rearrangements known as convergent extension. During PCP signaling, core PCP proteins are sorted asymmetrically along the polarization axis; this sorting is thought to direct coordinated downstream morphogenetic changes across the entire tissue. Here, we show that a gene encoding a ciliary protein (a 'ciliary gene'), Ift88, also known as Polaris, is required for establishing epithelial PCP and for convergent extension of the cochlear duct of Mus musculus. We also show that the proper positioning of ciliary basal bodies and the formation of polarized cellular structures are disrupted in mice with mutant ciliary proteins ('ciliary mutants'), whereas core PCP proteins are partitioned normally along the polarization axis. Thus, our data uncover a distinct requirement for ciliary genes in basal body positioning and morphological polarization during PCP regulation.
- Department of Cell Biology, Emory University School of Medicine, 615 Michael St., Atlanta, Georgia 30322, USA.
- Department of Cell Biology, University of Alabama, Birmingham, Alabama 35294, USA.
- Institut national de la santé et de la recherche médicale (INSERM) UMRS 587, Unité de Génétique des Déficits Sensoriels, Collège de France, Institut Pasteur, 75724 Paris, France.
Correspondence to: Ping Chen1 e-mail: ping.chen@emory.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Basal bodies, kinocilia and planar cell polarityNature Genetics News and Views (01 Jan 2008)
Hedgehogs on the road to polarityNature Genetics News and Views (01 Mar 2006)
See all 9 matches for News And ViewsRESEARCH
The mechanisms of acute ischemic injury in the cell processes of developing white matter astrocytesJournal of Cerebral Blood Flow & Metabolism Original Article
Is the nitric oxide system involved in genetic hypertension in Dahl rats?Kidney International Original Article
See all 61 matches for Research
