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Brief Communication

Nature Genetics 39, 951–953 (1 August 2007) | doi:10.1038/ng2067

Common variants in WFS1 confer risk of type 2 diabetes

Manjinder S Sandhu , Michael N Weedon , Katherine A Fawcett , Jon Wasson , Sally L Debenham , Allan Daly , Hana Lango , Timothy M Frayling , Rosalind J Neumann , Richard Sherva , Ilana Blech , Paul D Pharoah , Colin N A Palmer , Charlotte Kimber , Roger Tavendale , Andrew D Morris , Mark I McCarthy , Mark Walker , Graham Hitman , Benjamin Glaser , M Alan Permutt , Andrew T Hattersley , Nicholas J Wareham & In|[ecirc]|s Barroso

We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk.