Brief Communication abstract
Nature Genetics 39, 954 - 956 (2007)
Published online: 8 July 2007 | doi:10.1038/ng2098
A common genetic risk factor for colorectal and prostate cancer
Christopher A Haiman1, Loïc Le Marchand2, Jennifer Yamamato2, Daniel O Stram1, Xin Sheng1, Laurence N Kolonel2, Anna H Wu1, David Reich3,4 & Brian E Henderson1
Variants on chromosome 8q24 contribute risk for prostate cancer; here, we tested whether they also modulate risk for colorectal cancer. We studied 1,807 affected individuals and 5,511 controls and found that one variant, rs6983267, is also significantly associated with colorectal cancer (odds ratio = 1.22; P = 4.4 
10-6) and that the apportionment of risk among the variants differs significantly between the two cancers. Comprehensive testing in the region uncovered variants capturing significant additional risk. Our results show that variants at 8q24 have different effects on cancer development that depend on the tissue type.
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
- Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA.
- Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
- Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Correspondence to: Christopher A Haiman1 e-mail: haiman@usc.edu
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