News and Views


Nature Genetics 39, 708 - 710 (2007)
doi:10.1038/ng0607-708

'Unleashed' natural killers hinder HIV

Marcus Altfeld1 & Philip Goulder2

  1. Marcus Altfeld is at Partners AIDS Research Center, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA.
  2. Philip Goulder is at Partners AIDS Research Center and at the Department of Paediatrics, University of Oxford, Oxford OX1 3SY, UK. e-mail: Philip.Goulder@paediatrics.ox.ac.uk


A new study reports that specific combinations of killer immunoglobulin-like receptor and HLA-B alleles influence AIDS progression and plasma HIV RNA levels in HIV-infected individuals. These results suggest that natural killer cells have an important role in recognizing and limiting HIV infection.

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