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Letter

Nature Genetics 39, 264–268 (1 February 2007) | doi:10.1038/ng1944

Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster

Gisele Passador-Gurgel , Wen-Ping Hsieh , Priscilla Hunt , Nigel Deighton & Greg Gibson

Although most genetic association studies are performed with the intention of detecting nucleotide polymorphisms that are correlated with a complex trait, transcript abundance should also be expected to associate with diseases or phenotypes. We performed a scan for such quantitative trait transcripts in adult female heads of the fruit fly (Drosophila melanogaster) that might explain variation for nicotine resistance.