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Technical Report

Nature Genetics 39, 1522–1527 (1 December 2007) | doi:10.1038/ng.2007.42

Genome-wide in situ exon capture for selective resequencing

Emily Hodges , Zhenyu Xuan , Vivekanand Balija , Melissa Kramer , Michael N Molla , Steven W Smith , Christina M Middle , Matthew J Rodesch , Thomas J Albert , Gregory J Hannon & W Richard McCombie

Increasingly powerful sequencing technologies are ushering in an era of personal genome sequences and raising the possibility of using such information to guide medical decisions. Genome resequencing also promises to accelerate the identification of disease-associated mutations.