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Brief Communication

Nature Genetics 39, 1440–1442 (1 December 2007) | doi:10.1038/ng.2007.29

Cystatin C inhibits amyloid-|[beta]| deposition in Alzheimer's disease mouse models

Weiqian Mi , Monika Pawlik , Magdalena Sastre , Sonia S Jung , David S Radvinsky , Andrew M Klein , John Sommer , Stephen D Schmidt , Ralph A Nixon , Paul M Mathews & Efrat Levy

Using transgenic mice expressing human cystatin C (encoded by CST3), we show that cystatin C binds soluble amyloid-β peptide and inhibits cerebral amyloid deposition in amyloid-β precursor protein (APP) transgenic mice. Cystatin C expression twice that of the endogenous mouse cystatin C was sufficient to substantially diminish amyloid-β deposition.