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Letter

Nature Genetics 39, 1507–1511 (1 December 2007) | doi:10.1038/ng.2007.21

RNA polymerase is poised for activation across the genome

Ginger W Muse , Daniel A Gilchrist , Sergei Nechaev , Ruchir Shah , Joel S Parker , Sherry F Grissom , Julia Zeitlinger & Karen Adelman

Regulation of gene expression is integral to the development and survival of all organisms. Transcription begins with the assembly of a pre-initiation complex at the gene promoter, followed by initiation of RNA synthesis and the transition to productive elongation.