News and Views
Nature Genetics 39, 1191 - 1192 (2007)
doi:10.1038/ng1007-1191
How microRNAs choose their targets
Ivo L Hofacker1
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Ivo L. Hofacker is at the Institute for Theoretical Chemistry, University of Vienna, Währingerstra
e 17, A-1090 Wien, Austria. e-mail: ivo@tbi.univie.ac.at
Abstract
The growing list of known microRNAs is only as useful as our ability to identify the mRNA targets they control. A new study stresses the role of messenger RNA structure in microRNA target recognition and suggests that binding of the RNA-induced silencing complex is largely controlled by the thermodynamics of RNA-RNA interactions.
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