News and Views
Nature Genetics 39, 11 - 12 (2007)
doi:10.1038/ng0107-11
Telomeres, p21 and the cancer-aging hypothesis
Jessica F Bell1 & Norman E Sharpless1
- Jessica F. Bell and Norman E. Sharpless are in the Departments of Medicine and Genetics, The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA. e-mail: nes@med.unc.edu
Abstract
Telomere dysfunction suppresses cancer through the p53 tumor suppressor pathway but also contributes to aging. A new study suggests that these effects of dysfunctional telomeres may be separable, such that aging—but not cancer suppression—depends on the p21 cell cycle inhibitor.
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