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Letter

Nature Genetics 38, 1082–1087 (1 September 2006) | doi:10.1038/ng1869

Dual feedback loops in the GAL regulon suppress cellular heterogeneity in yeast

Stephen A Ramsey , Jennifer J Smith , David Orrell , Marcello Marelli , Timothy W Petersen , Pedro de Atauri , Hamid Bolouri & John D Aitchison

Transcriptional noise is known to be an important cause of cellular heterogeneity and phenotypic variation. The extent to which molecular interaction networks may have evolved to either filter or exploit transcriptional noise is a much debated question.