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Letter
Nature Genetics - 38, 1082 - 1087 (2006)
Published online: 27 August 2006; | doi:10.1038/ng1869

Dual feedback loops in the GAL regulon suppress cellular heterogeneity in yeast

Stephen A Ramsey, Jennifer J Smith, David Orrell, Marcello Marelli, Timothy W Petersen, Pedro de Atauri, Hamid Bolouri & John D Aitchison

Institute for Systems Biology, 1441 N 34th Street, Seattle, Washington 98103, USA.

Correspondence should be addressed to Hamid Bolouri hbolouri@systemsbiology.org or John D Aitchison jaitchison@systemsbiology.org

Transcriptional noise is known to be an important cause of cellular heterogeneity and phenotypic variation. The extent to which molecular interaction networks may have evolved to either filter or exploit transcriptional noise is a much debated question. The yeast genetic network regulating galactose metabolism involves two proteins, Gal3p and Gal80p, that feed back positively and negatively, respectively, on GAL gene expression. Using kinetic modeling and experimental validation, we demonstrate that these feedback interactions together are important for (i) controlling the cell-to-cell variability of GAL gene expression and (ii) ensuring that cells rapidly switch to an induced state for galactose uptake.


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Nature Genetics
ISSN: 1061-4036
EISSN: 1546-1718
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