Gina Mundschau and John Crispino are at the Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois
60637, USA. crispino@huggins.bsd.uchicago.edu
Acquired somatic mutations in the transcription factor GATA1 are a defining feature of acute megakaryocytic leukemia in children with Down syndrome. A new study shows that similar inherited GATA1 mutations do not promote leukemia in the absence of trisomy 21 but lead to defects in multiple hematopoietic lineages.
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