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Letter

Nature Genetics 38, 350–355 (1 March 2006) | doi:10.1038/ng1731

Identification of an imprinting control region affecting the expression of all transcripts in the Gnas cluster

Christine M Williamson , Martin D Turner , Simon T Ball , Wade T Nottingham , Peter Glenister , Martin Fray , Zuzanna Tymowska-Lalanne , Antonius Plagge , Nicola Powles-Glover , Gavin Kelsey , Mark Maconochie & Jo Peters

Genomic imprinting results in allele-specific silencing according to parental origin. Silencing is brought about by imprinting control regions (ICRs) that are differentially marked in gametogenesis.