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Letter

Nature Genetics 38, 1323–1328 (1 November 2006) | doi:10.1038/ng1895

Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer

Li-Ying Sung , Shaorong Gao , Hongmei Shen , Hui Yu , Yifang Song , Sadie L Smith , Ching-Chien Chang , Kimiko Inoue , Lynn Kuo , Jin Lian , Ao Li , X Cindy Tian , David P Tuck , Sherman M Weissman , Xiangzhong Yang & Tao Cheng

Since the creation of Dolly via somatic cell nuclear transfer (SCNT), more than a dozen species of mammals have been cloned using this technology. One hypothesis for the limited success of cloning via SCNT (1%–5%) is that the clones are likely to be derived from adult stem cells.