Access

Letter

Nature Genetics 38, 1335–1340 (1 November 2006) | doi:10.1038/ng1903

Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6)

Christopher R Ingraham , Akira Kinoshita , Shinji Kondo , Baoli Yang , Samin Sajan , Kurt J Trout , Margaret I Malik , Martine Dunnwald , Stephen L Goudy , Michael Lovett , Jeffrey C Murray & Brian C Schutte

Transcription factor paralogs may share a common role in staged or overlapping expression in specific tissues, as in the Hox family. In other cases, family members have distinct roles in a range of embryologic, differentiation or response pathways (as in the Tbx and Pax families).