Blanche Capel is in the Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA. b.capel@cellbio.duke.edu
Female-to-male sex reversal is an extremely rare and puzzling phenomenon. A new study identifies mutations in the gene encoding R-spondin1 in XX sex-reversed individuals and suggests that antagonistic pathways in the bipotential gonad regulate sex determination.
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