Nature Genetics 38, 101 - 106 (2006)
Published online: 11 December 2005; | doi:10.1038/ng1699
Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethalityRyuichi Ono1, 2, Kenji Nakamura3, Kimiko Inoue2, 4, Mie Naruse1, Takako Usami5, Noriko Wakisaka-Saito1, 2, 6, 7, Toshiaki Hino3, Rika Suzuki-Migishima3, Narumi Ogonuki4, Hiromi Miki4, Takashi Kohda1, 2, Atsuo Ogura2, 4, Minesuke Yokoyama2, 3, 8, Tomoko Kaneko-Ishino2, 7
& Fumitoshi Ishino1, 21
Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan. 2
CREST, Japan Science and Technology Agency (JST), 4-1-8 Hon-machi, Kawaguchi, Saitama 332-0011, Japan. 3
Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194-8511, Japan. 4
BioResource Center, RIKEN, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan. 5
Facility for Recombinant Mice, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan. 6
Division for Gene Research, Center for Biological Resources and Informatics, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan. 7
School of Health Sciences, Tokai University, Bohseidai, Isehara, Kanagawa 259-1193, Japan. 8
Present address: Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Niigata 951-8585, Japan.
Correspondence should be addressed to Tomoko Kaneko-Ishino tkanekoi@is.icc.u-tokai.ac.jp or Fumitoshi Ishino fishino.epgn@mri.tmd.ac.jp By comparing mammalian genomes, we and others have identified actively transcribed Ty3/gypsy retrotransposon-derived genes with highly conserved DNA sequences and insertion sites1,
2,
3,
4,
5,
6. To elucidate the functions of evolutionarily conserved retrotransposon-derived genes in mammalian development, we produced mice that lack one of these genes, Peg10 (paternally expressed 10)1,
2,
3,
7, which is a paternally expressed imprinted gene on mouse proximal chromosome 6. The Peg10 knockout mice showed early embryonic lethality owing to defects in the placenta. This indicates that Peg10 is critical for mouse parthenogenetic development and provides the first direct evidence of an essential role of an evolutionarily conserved retrotransposon-derived gene in mammalian development.
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