Soni Lacefield and Andrew Murray are in the Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave., Cambridge, Massachusetts 02138, USA. amurray@mcb.harvard.edu
The spindle checkpoint delays the cell cycle when chromosomes are not properly attached to the mitotic or meiotic spindle, giving cells time to correct the error. A new study now strengthens the connection between checkpoint failure and human aneuploidies by showing that the spindle checkpoint component Mad3p is required for accurate segregation of meiotic chromosomes that have not recombined with each other.
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