Gregory G. Germino is at the Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. ggermino@jhmi.edu
Inversin is a component of a poorly understood cilia-based mechanism responsible for specifying the left-right axis during development and for maintaining normal kidney architecture throughout life. A new study now suggests that inversin might act as a flow-regulated molecular switch between canonical and noncanonical Wnt pathways, providing insights into the mechanisms underlying cilia-based signaling processes.
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